Reaction Details |
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Target | Cytochrome P450 11B1, mitochondrial |
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Ligand | BDBM50439057 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_980062 (CHEMBL2423499) |
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IC50 | 2.0±n/a nM |
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Citation | Emmerich, J; Hu, Q; Hanke, N; Hartmann, RW Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)pyridine type. J Med Chem56:6022-32 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 11B1, mitochondrial |
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Name: | Cytochrome P450 11B1, mitochondrial |
Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
Type: | Enzyme |
Mol. Mass.: | 57591.44 |
Organism: | Homo sapiens (Human) |
Description: | P15538 |
Residue: | 503 |
Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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BDBM50439057 |
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n/a |
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Name | BDBM50439057 |
Synonyms: | CHEMBL2417553 |
Type | Small organic molecule |
Emp. Form. | C18H16N2 |
Mol. Mass. | 260.333 |
SMILES | Cc1cncc(Cc2ccc(nc2)-c2ccccc2)c1 |
Structure |
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