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TargetThymidine phosphorylase
LigandBDBM50439106
Substrate/Competitorn/a
Meas. Tech.ChEMBL_977519 (CHEMBL2423136)
Ki 20090±n/a nM
Citation Bera, HTan, BJSun, LDolzhenko, AVChui, WKChiu, GN A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities. Eur J Med Chem67:325-34 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thymidine phosphorylase
Name:Thymidine phosphorylase
Synonyms:ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase
Type:Enzyme
Mol. Mass.:49948.87
Organism:Homo sapiens (Human)
Description:The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319).
Residue:482
Sequence:
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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  Blast E-value cutoff:
BDBM50439106
n/a
NameBDBM50439106
Synonyms:CHEMBL2418074
TypeSmall organic molecule
Emp. Form.C10H5Cl2N5OS
Mol. Mass.314.151
SMILESClc1ccc(cc1Cl)-c1nc2[nH]c(=S)[nH]c(=O)n2n1
Structure
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