Reaction Details |
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Target | Short transient receptor potential channel 6 |
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Ligand | BDBM50439220 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_978640 (CHEMBL2422303) |
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IC50 | 16±n/a nM |
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Citation | Washburn, DG; Holt, DA; Dodson, J; McAtee, JJ; Terrell, LR; Barton, L; Manns, S; Waszkiewicz, A; Pritchard, C; Gillie, DJ; Morrow, DM; Davenport, EA; Lozinskaya, IM; Guss, J; Basilla, JB; Negron, LK; Klein, M; Willette, RN; Fries, RE; Jensen, TC; Xu, X; Schnackenberg, CG; Marino, JP The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore. Bioorg Med Chem Lett23:4979-84 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Short transient receptor potential channel 6 |
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Name: | Short transient receptor potential channel 6 |
Synonyms: | TRP-6 | TRP6 | TRPC6 | TRPC6_HUMAN | Transient receptor protein 6 |
Type: | PROTEIN |
Mol. Mass.: | 106326.67 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_107640 |
Residue: | 931 |
Sequence: | MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGS
DNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEE
CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAI
LSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLR
KGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALEL
SNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR
PNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFL
ALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNA
KQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAAS
FIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYA
IAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYI
GAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLL
NMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKL
KKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSS
EDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLE
EKSQNTEDLAELIRELGEKLSMEPNQEETNR
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BDBM50439220 |
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n/a |
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Name | BDBM50439220 |
Synonyms: | CHEMBL2418807 |
Type | Small organic molecule |
Emp. Form. | C18H21N3O3S |
Mol. Mass. | 359.443 |
SMILES | CC1CCCN(C1C)C(=O)c1csc(Nc2ccc3OCOc3c2)n1 |
Structure |
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