Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetArginase-1
LigandBDBM50350311
Substrate/Competitorn/a
Meas. Tech.ChEMBL_978893
IC50 1470±n/a nM
Citation Golebiowski AWhitehouse DBeckett RPVan Zandt MJi MKRyder TRJagdmann EAndreoli MLee YSheeler RConway BOlczak JMazur MCzestkowski WPiotrowska WCousido-Siah ARuiz FXMitschler APodjarny ASchroeter H Synthesis of quaternarya-amino acid-based arginase inhibitors via the Ugi reaction. Bioorg Med Chem Lett 23:4837-41 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Arginase-1
Name:Arginase-1
Synonyms:ARG1 | Liver-type arginase | Type I arginase
Type:PROTEIN
Mol. Mass.:34737.53
Organism:Homo sapiens (Human)
Description:ChEMBL_978893
Residue:322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50350311
n/a
NameBDBM50350311
Synonyms:CHEMBL1812661
TypeSmall organic molecule
Emp. Form.C6H14BNO4
Mol. Mass.174.991
SMILES[NH3+][C@@H](CCCCB(O)O)C([O-])=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: