| Reaction Details |
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 | Report a problem with these data |
| Target | Arginase-1 |
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| Ligand | BDBM50439243 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_978893 (CHEMBL2423684) |
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| IC50 | 100±n/a nM |
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| Citation |  Golebiowski, A; Whitehouse, D; Beckett, RP; Van Zandt, M; Ji, MK; Ryder, TR; Jagdmann, E; Andreoli, M; Lee, Y; Sheeler, R; Conway, B; Olczak, J; Mazur, M; Czestkowski, W; Piotrowska, W; Cousido-Siah, A; Ruiz, FX; Mitschler, A; Podjarny, A; Schroeter, H Synthesis of quaternarya-amino acid-based arginase inhibitors via the Ugi reaction. Bioorg Med Chem Lett23:4837-41 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Arginase-1 |
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| Name: | Arginase-1 |
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| Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34737.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_978893 |
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| Residue: | 322 |
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| Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
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| BDBM50439243 |
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| n/a |
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| Name | BDBM50439243 |
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| Synonyms: | CHEMBL2418998 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H31BCl2N2O4 |
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| Mol. Mass. | 445.188 |
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| SMILES | NC(CCCCB(O)O)(C1CCN(CCCc2ccc(Cl)cc2Cl)CC1)C(O)=O |
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| Structure | 
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