Reaction Details |
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Target | G protein-activated inward rectifier potassium channel 4 |
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Ligand | BDBM50241582 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_980165 (CHEMBL2423999) |
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EC50 | >100000±n/a nM |
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Citation | Ramos-Hunter, SJ; Engers, DW; Kaufmann, K; Du, Y; Lindsley, CW; Weaver, CD; Sulikowski, GA Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators. Bioorg Med Chem Lett23:5195-8 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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G protein-activated inward rectifier potassium channel 4 |
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Name: | G protein-activated inward rectifier potassium channel 4 |
Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 |
Type: | PROTEIN |
Mol. Mass.: | 47658.06 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_107914 |
Residue: | 419 |
Sequence: | MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
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BDBM50241582 |
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n/a |
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Name | BDBM50241582 |
Synonyms: | (S)-7-((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-2-yloxy)-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one | CHEMBL451532 | cid_25075 | cid_442428 | naringin |
Type | Small organic molecule |
Emp. Form. | C27H32O14 |
Mol. Mass. | 580.5346 |
SMILES | C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc2cc(O)c3C(=O)C[C@H](Oc3c2)c2ccc(O)cc2)[C@H](O)[C@H](O)[C@H]1O |r| |
Structure |
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