| Reaction Details |
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 | Report a problem with these data |
| Target | G protein-activated inward rectifier potassium channel 4 |
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| Ligand | BDBM50439410 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_980171 (CHEMBL2424209) |
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| EC50 | 240±n/a nM |
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| Citation |  Ramos-Hunter, SJ; Engers, DW; Kaufmann, K; Du, Y; Lindsley, CW; Weaver, CD; Sulikowski, GA Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators. Bioorg Med Chem Lett23:5195-8 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G protein-activated inward rectifier potassium channel 4 |
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| Name: | G protein-activated inward rectifier potassium channel 4 |
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| Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47658.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107914 |
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| Residue: | 419 |
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| Sequence: | MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
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| BDBM50439410 |
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| n/a |
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| Name | BDBM50439410 |
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| Synonyms: | CHEMBL2420532 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10Cl2F3NO |
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| Mol. Mass. | 348.147 |
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| SMILES | FC(F)(F)c1cc(NC(=O)Cc2ccccc2Cl)ccc1Cl |
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| Structure | 
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