| Reaction Details |
|---|
 | Report a problem with these data |
| Target | G protein-activated inward rectifier potassium channel 4 |
|---|
| Ligand | BDBM50439415 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_980171 (CHEMBL2424209) |
|---|
| EC50 | 3300±n/a nM |
|---|
| Citation |  Ramos-Hunter, SJ; Engers, DW; Kaufmann, K; Du, Y; Lindsley, CW; Weaver, CD; Sulikowski, GA Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators. Bioorg Med Chem Lett23:5195-8 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| G protein-activated inward rectifier potassium channel 4 |
|---|
| Name: | G protein-activated inward rectifier potassium channel 4 |
|---|
| Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47658.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_107914 |
|---|
| Residue: | 419 |
|---|
| Sequence: | MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
|
|
|
|---|
| BDBM50439415 |
|---|
| n/a |
|---|
| Name | BDBM50439415 |
|---|
| Synonyms: | CHEMBL2420549 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H18N4O3S |
|---|
| Mol. Mass. | 358.415 |
|---|
| SMILES | CN(C)S(=O)(=O)c1cc(NC(=O)Nc2cccc(c2)C#N)ccc1C |
|---|
| Structure | 
|
|---|
Search and Browse
