| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform epsilon |
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| Ligand | BDBM50364141 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_977606 (CHEMBL2423573) |
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| IC50 | 29±n/a nM |
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| Citation |  Mente, S; Arnold, E; Butler, T; Chakrapani, S; Chandrasekaran, R; Cherry, K; DiRico, K; Doran, A; Fisher, K; Galatsis, P; Green, M; Hayward, M; Humphrey, J; Knafels, J; Li, J; Liu, S; Marconi, M; McDonald, S; Ohren, J; Paradis, V; Sneed, B; Walton, K; Wager, T Ligand-protein interactions of selective casein kinase 1d inhibitors. J Med Chem56:6819-28 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform epsilon |
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| Name: | Casein kinase I isoform epsilon |
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| Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 47340.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49674 |
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| Residue: | 416 |
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| Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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| BDBM50364141 |
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| n/a |
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| Name | BDBM50364141 |
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| Synonyms: | CHEMBL1951415 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20FN5 |
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| Mol. Mass. | 337.394 |
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| SMILES | Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1 |
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| Structure | 
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