| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 |
|---|
| Ligand | BDBM50439464 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_978338 (CHEMBL2424119) |
|---|
| IC50 | 47000±n/a nM |
|---|
| Citation |  Allen, CE; Chow, CL; Caldwell, JJ; Westwood, IM; van Montfort, RL; Collins, I Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases. Bioorg Med Chem21:5707-24 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 1 |
|---|
| Name: | Mitogen-activated protein kinase 1 |
|---|
| Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
|---|
| Type: | Ser/Thr Protein Kinase |
|---|
| Mol. Mass.: | 41392.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P28482 |
|---|
| Residue: | 360 |
|---|
| Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
|
|
|
|---|
| BDBM50439464 |
|---|
| n/a |
|---|
| Name | BDBM50439464 |
|---|
| Synonyms: | CHEMBL2420909 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H20N6 |
|---|
| Mol. Mass. | 272.3488 |
|---|
| SMILES | C1CCC2(CCN(CC2)c2ncnc3nc[nH]c23)NC1 |
|---|
| Structure | 
|
|---|
Search and Browse
