Reaction Details | |||
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Target | Endoplasmin | ||
Ligand | BDBM50439624 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_977713 (CHEMBL2424070) | ||
Kd | 31±n/a nM | ||
Citation | Taldone, T; Patel, PD; Patel, M; Patel, HJ; Evans, CE; Rodina, A; Ochiana, S; Shah, SK; Uddin, M; Gewirth, D; Chiosis, G Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. J Med Chem56:6803-18 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Endoplasmin | |||
Name: | Endoplasmin | ||
Synonyms: | ENPL_CANLF | GRP94 | HSP90B1 | Heat shock protein 90 beta | TRA1 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 92464.42 | ||
Organism: | Canis familiaris | ||
Description: | ChEMBL_1478277 | ||
Residue: | 804 | ||
Sequence: |
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BDBM50439624 | |||
n/a | |||
Name | BDBM50439624 | ||
Synonyms: | CHEMBL1910764 | ||
Type | Small organic molecule | ||
Emp. Form. | C39H32IN7O7S2 | ||
Mol. Mass. | 901.749 | ||
SMILES | CC(C)N(CCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)ncnc12)C(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12 |(24.17,-3.37,;24.17,-4.91,;25.5,-5.68,;22.84,-5.68,;21.5,-4.92,;21.5,-3.38,;20.16,-2.61,;20.16,-1.07,;21.08,.17,;22.62,.16,;23.39,1.49,;24.93,1.47,;25.71,2.81,;27.21,3.11,;27.38,4.64,;25.98,5.28,;24.95,4.14,;23.4,4.14,;22.63,2.82,;21.09,2.82,;20.17,1.42,;18.71,.95,;17.4,1.72,;17.41,3.26,;16.08,.96,;16.07,-.57,;17.39,-1.34,;18.7,-.59,;22.84,-7.22,;21.5,-8,;24.17,-7.99,;24.17,-9.53,;22.84,-10.31,;22.84,-11.85,;24.17,-12.61,;25.51,-11.84,;25.51,-10.3,;27.04,-11.84,;27.82,-13.17,;27.81,-10.5,;24.17,-14.14,;22.84,-14.92,;21.5,-14.15,;20.17,-14.93,;20.17,-16.47,;18.84,-17.24,;21.51,-17.24,;22.83,-16.47,;24.17,-17.24,;25.51,-16.46,;26.84,-17.23,;28.17,-16.46,;29.5,-17.23,;28.17,-14.92,;26.84,-14.15,;25.51,-14.92,)| | ||
Structure |