| Reaction Details |
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 | Report a problem with these data |
| Target | N-acylethanolamine-hydrolyzing acid amidase |
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| Ligand | BDBM50439653 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_978419 (CHEMBL2421061) |
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| IC50 | 5.0±n/a nM |
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| Citation |  Ponzano, S; Bertozzi, F; Mengatto, L; Dionisi, M; Armirotti, A; Romeo, E; Berteotti, A; Fiorelli, C; Tarozzo, G; Reggiani, A; Duranti, A; Tarzia, G; Mor, M; Cavalli, A; Piomelli, D; Bandiera, T Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors. J Med Chem56:6917-34 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-acylethanolamine-hydrolyzing acid amidase |
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| Name: | N-acylethanolamine-hydrolyzing acid amidase |
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| Synonyms: | ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT |
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| Type: | Enzyme |
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| Mol. Mass.: | 40073.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02083 |
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| Residue: | 359 |
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| Sequence: | MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLV
RAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAY
ESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGL
WTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKT
PLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDR
RTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
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| BDBM50439653 |
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| n/a |
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| Name | BDBM50439653 |
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| Synonyms: | CHEMBL2419830 | US9353075, 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H27NO4 |
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| Mol. Mass. | 297.3899 |
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| SMILES | C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCC1CCCCC1 |r| |
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| Structure | 
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