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TargetProtein Wnt-3a
LigandBDBM50439791
Substrate/Competitorn/a
Meas. Tech.ChEMBL_977441 (CHEMBL2422476)
IC50 3.5±n/a nM
Citation Shultz, MDCheung, AKKirby, CAFirestone, BFan, JChen, CHChen, ZChin, DNDipietro, LFazal, AFeng, YFortin, PDGould, TLagu, BLei, HLenoir, FMajumdar, DOchala, EPalermo, MGPham, LPu, MSmith, TStams, TTomlinson, RCTouré, BBVisser, MWang, RMWaters, NJShao, W Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. J Med Chem56:6495-511 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein Wnt-3a
Name:Protein Wnt-3a
Synonyms:WNT3A | WNT3A_HUMAN
Type:PROTEIN
Mol. Mass.:39379.02
Organism:Homo sapiens (Human)
Description:ChEMBL_1469237
Residue:352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYV
EIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGV
AFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDAR
SAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASE
MVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVS
SHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50439791
n/a
NameBDBM50439791
Synonyms:CHEMBL2419706 | US9181266, 5
TypeSmall organic molecule
Emp. Form.C27H34N4O5
Mol. Mass.494.5827
SMILESCOc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc3CCOCc3c(=O)[nH]2)CC1
Structure
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