Reaction Details |
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Target | Protein Wnt-3a |
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Ligand | BDBM50439791 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_977441 (CHEMBL2422476) |
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IC50 | 3.5±n/a nM |
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Citation | Shultz, MD; Cheung, AK; Kirby, CA; Firestone, B; Fan, J; Chen, CH; Chen, Z; Chin, DN; Dipietro, L; Fazal, A; Feng, Y; Fortin, PD; Gould, T; Lagu, B; Lei, H; Lenoir, F; Majumdar, D; Ochala, E; Palermo, MG; Pham, L; Pu, M; Smith, T; Stams, T; Tomlinson, RC; Touré, BB; Visser, M; Wang, RM; Waters, NJ; Shao, W Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. J Med Chem56:6495-511 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein Wnt-3a |
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Name: | Protein Wnt-3a |
Synonyms: | WNT3A | WNT3A_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 39379.02 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1469237 |
Residue: | 352 |
Sequence: | MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYV
EIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGV
AFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDAR
SAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASE
MVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVS
SHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
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BDBM50439791 |
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n/a |
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Name | BDBM50439791 |
Synonyms: | CHEMBL2419706 | US9181266, 5 |
Type | Small organic molecule |
Emp. Form. | C27H34N4O5 |
Mol. Mass. | 494.5827 |
SMILES | COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc3CCOCc3c(=O)[nH]2)CC1 |
Structure |
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