| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxanthine-guanine phosphoribosyltransferase |
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| Ligand | BDBM50439833 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_978181 (CHEMBL2423189) |
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| Ki | 1600±n/a nM |
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| Citation |  Baszczynski, O; Hocková, D; Janeba, Z; Holý, A; Jansa, P; Dracínský, M; Keough, DT; Guddat, LW The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Eur J Med Chem67:81-9 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxanthine-guanine phosphoribosyltransferase |
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| Name: | Hypoxanthine-guanine phosphoribosyltransferase |
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| Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
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| Type: | Protein |
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| Mol. Mass.: | 24579.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00492 |
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| Residue: | 218 |
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| Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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| BDBM50439833 |
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| n/a |
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| Name | BDBM50439833 |
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| Synonyms: | CHEMBL2420080 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H14FN4O5P |
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| Mol. Mass. | 320.2141 |
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| SMILES | OP(O)(=O)CCO[C@H](CF)Cn1cnc2c1nc[nH]c2=O |r| |
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| Structure | 
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