Reaction Details |
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Target | Hypoxanthine-guanine phosphoribosyltransferase |
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Ligand | BDBM50439836 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_978181 (CHEMBL2423189) |
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Ki | 100±n/a nM |
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Citation | Baszczynski, O; Hocková, D; Janeba, Z; Holý, A; Jansa, P; Dracínský, M; Keough, DT; Guddat, LW The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Eur J Med Chem67:81-9 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hypoxanthine-guanine phosphoribosyltransferase |
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Name: | Hypoxanthine-guanine phosphoribosyltransferase |
Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
Type: | Protein |
Mol. Mass.: | 24579.61 |
Organism: | Homo sapiens (Human) |
Description: | P00492 |
Residue: | 218 |
Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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BDBM50439836 |
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n/a |
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Name | BDBM50439836 |
Synonyms: | CHEMBL2420072 |
Type | Small organic molecule |
Emp. Form. | C10H15FN5O5P |
Mol. Mass. | 335.2288 |
SMILES | Nc1nc2n(C[C@@H](CF)OCCP(O)(O)=O)cnc2c(=O)[nH]1 |r| |
Structure |
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