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TargetGrowth hormone secretagogue receptor type 1
LigandBDBM50386955
Substrate/Competitorn/a
Meas. Tech.ChEMBL_982014 (CHEMBL2428369)
Ki 5.5±n/a nM
Citation McClure, KFJackson, MCameron, KOKung, DWPerry, DAOrr, STZhang, YKohrt, JTu, MGao, HFernando, DJones, RErasga, NWang, GPolivkova, JJiao, WSwartz, RUeno, HBhattacharya, SKStock, IAVarma, SBagdasarian, VPerez, SKelly-Sullivan, DWang, RKong, JCornelius, PMichael, LLee, EJanssen, ASteyn, SJLapham, KGoosen, T Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor. Bioorg Med Chem Lett23:5410-4 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Growth hormone secretagogue receptor type 1
Name:Growth hormone secretagogue receptor type 1
Synonyms:GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:Receptor
Mol. Mass.:41334.57
Organism:Homo sapiens (Human)
Description:Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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  Blast E-value cutoff:
BDBM50386955
n/a
NameBDBM50386955
Synonyms:CHEMBL2048820
TypeSmall organic molecule
Emp. Form.C24H26ClN7OS
Mol. Mass.496.028
SMILESCc1cn2cc(CC(=O)N3CCC4(CN(Cc5ccc(cc5Cl)-n5nccn5)C4)CC3)nc2s1
Structure
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