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TargetMuscarinic acetylcholine receptor M2
LigandBDBM50440260
Substrate/Competitorn/a
Meas. Tech.ChEMBL_982012
Ki 1202±n/a nM
Citation McClure KFJackson MCameron KOKung DWPerry DAOrr STZhang YKohrt JTu MGao HFernando DJones RErasga NWang GPolivkova JJiao WSwartz RUeno HBhattacharya SKStock IAVarma SBagdasarian VPerez SKelly-Sullivan DWang RKong JCornelius PMichael LLee EJanssen ASteyn SJLapham KGoosen T Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor. Bioorg Med Chem Lett 23:5410-4 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M2
Name:Muscarinic acetylcholine receptor M2 and M5
Synonyms:CHRM2 | Cholinergic, muscarinic M2 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:GPCR
Mol. Mass.:51730.61
Organism:Homo sapiens (Human)
Description:P08172
Residue:466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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  Blast E-value cutoff:
BDBM50440260
n/a
NameBDBM50440260
Synonyms:CHEMBL2426676
TypeSmall organic molecule
Emp. Form.C29H32N4O2
Mol. Mass.468.59
SMILESCOc1ccc(CC(=O)N2CCC3(CN(C3)[C@H]3CCc4cc(ccc34)-c3ncccn3)CC2)cc1 |r|
Structure
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