| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 2A |
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| Ligand | BDBM26106 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_982479 (CHEMBL2427605) |
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| IC50 | 45000±n/a nM |
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| Citation |  Suzuki, T; Ozasa, H; Itoh, Y; Zhan, P; Sawada, H; Mino, K; Walport, L; Ohkubo, R; Kawamura, A; Yonezawa, M; Tsukada, Y; Tumber, A; Nakagawa, H; Hasegawa, M; Sasaki, R; Mizukami, T; Schofield, CJ; Miyata, N Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem56:7222-31 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 2A |
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| Name: | Lysine-specific demethylase 2A |
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| Synonyms: | AA1-1162 | CXXC8 | F-box and leucine-rich repeat protein 11 | FBL11 | FBL7 | FBXL11 | Homo sapiens lysine demethylase 2A (KDM2A) | JHDM1A | KDM2A | KDM2A_HUMAN | KIAA1004 | Lysine-specific demethylase 2A | Lysine-specific demethylase 2A (KDM2A) | NM_012308 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 132809.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 1162 |
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| Sequence: | MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGK
DFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIE
MTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHN
LELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFL
HSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKT
LAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPT
GIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP
HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRM
KQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEG
LLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT
SMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNP
SGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHC
PARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMS
VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLS
WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIR
DLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQ
SSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF
ISDLSINSLYCLSDEKLIQKIS
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| BDBM26106 |
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| n/a |
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| Name | BDBM26106 |
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| Synonyms: | CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylglycine | [(carboxymethyl)carbamoyl]formic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C4H5NO5 |
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| Mol. Mass. | 147.0862 |
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| SMILES | OC(=O)CNC(=O)C(O)=O |
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| Structure | 
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