| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2C8 |
|---|
| Ligand | BDBM50440369 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_983550 (CHEMBL2429620) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Grädler, U; Bomke, J; Musil, D; Dresing, V; Lehmann, M; Hölzemann, G; Greiner, H; Esdar, C; Krier, M; Heinrich, T Fragment-based discovery of focal adhesion kinase inhibitors. Bioorg Med Chem Lett23:5401-9 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2C8 |
|---|
| Name: | Cytochrome P450 2C8 |
|---|
| Synonyms: | CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55839.23 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10632 |
|---|
| Residue: | 490 |
|---|
| Sequence: | MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
|
|
|
|---|
| BDBM50440369 |
|---|
| n/a |
|---|
| Name | BDBM50440369 |
|---|
| Synonyms: | CHEMBL2425145 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H28N6O |
|---|
| Mol. Mass. | 428.5294 |
|---|
| SMILES | Cc1cn(cn1)-c1ccc(NC(=O)Nc2cc(nn2-c2ccc(C)cc2)C(C)(C)C)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
