| Reaction Details |
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 | Report a problem with these data |
| Target | C-C motif chemokine 2 |
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| Ligand | BDBM50257992 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_983389 (CHEMBL2428943) |
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| Ki | 50±n/a nM |
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| Citation |  Vilums, M; Zweemer, AJ; Yu, Z; de Vries, H; Hillger, JM; Wapenaar, H; Bollen, IA; Barmare, F; Gross, R; Clemens, J; Krenitsky, P; Brussee, J; Stamos, D; Saunders, J; Heitman, LH; Ijzerman, AP Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists. J Med Chem56:7706-14 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C motif chemokine 2 |
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| Name: | C-C motif chemokine 2 |
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| Synonyms: | CCL2 | CCL2_HUMAN | HC11 | MCAF | MCP-1 | MCP1 | Monocyte chemoattractant protein 1 | Monocyte chemotactic and activating factor | Monocyte chemotactic protein 1 | Monocyte secretory protein JE | SCYA2 | Small-inducible cytokine A2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 11032.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1363188 |
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| Residue: | 99 |
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| Sequence: | MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCP
KEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
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| BDBM50257992 |
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| n/a |
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| Name | BDBM50257992 |
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| Synonyms: | (1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(2,3-dihydro-1H-inden-1-ylamino)-1-isopropylcyclopentanecarboxamide | CHEMBL494019 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30F6N2O |
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| Mol. Mass. | 512.5303 |
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| SMILES | CC(C)[C@@]1(CC[C@H](C1)NC1CCc2ccccc12)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r| |
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| Structure | 
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