| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 3 |
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| Ligand | BDBM50440908 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_984988 (CHEMBL2433162) |
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| IC50 | >50000±n/a nM |
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| Citation |  Blackburn, C; Barrett, C; Chin, J; Garcia, K; Gigstad, K; Gould, A; Gutierrez, J; Harrison, S; Hoar, K; Lynch, C; Rowland, RS; Tsu, C; Ringeling, J; Xu, H Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform. J Med Chem56:7201-11 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 3 |
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| Name: | Histone deacetylase 3 |
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| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48829.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15379 |
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| Residue: | 428 |
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| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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| BDBM50440908 |
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| n/a |
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| Name | BDBM50440908 |
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| Synonyms: | CHEMBL2431912 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19N3O3 |
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| Mol. Mass. | 313.3511 |
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| SMILES | Cn1cccc1C(=O)N1CCCc2cc(ccc2C1)C(=O)NO |
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| Structure | 
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