| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform delta |
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| Ligand | BDBM50229971 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_986151 (CHEMBL2432951) |
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| IC50 | 353±n/a nM |
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| Citation |  Huart, AS; Saxty, B; Merritt, A; Nekulova, M; Lewis, S; Huang, Y; Vojtesek, B; Kettleborough, C; Hupp, TR A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway. Bioorg Med Chem Lett23:5578-85 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform delta |
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| Name: | Casein kinase I isoform delta |
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| Synonyms: | CK1, delta | Casein kinase 1 Delta | Casein kinase I delta | Casein kinase I isoform delta | Csnk1d | Hckid | KC1D_RAT | casein kinase 1, delta |
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| Type: | Enzyme |
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| Mol. Mass.: | 47342.73 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Q06486 |
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| Residue: | 415 |
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| Sequence: | MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ
GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRA
ADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPV
SGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
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| BDBM50229971 |
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| n/a |
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| Name | BDBM50229971 |
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| Synonyms: | 4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide | 4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide | 4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide | CHEMBL410456 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18N4O3 |
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| Mol. Mass. | 398.414 |
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| SMILES | NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCCOc2c1)-c1ccccn1 |
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| Structure | 
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