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TargetCytochrome P450 2D6
LigandBDBM50441246
Substrate/Competitorn/a
Meas. Tech.ChEMBL_984595 (CHEMBL2434089)
IC50>5000±n/a nM
Citation Schoenfeld, RCBourdet, DLBrameld, KAChin, Ede Vicente, JFung, AHarris, SFLee, EKLe Pogam, SLeveque, VLi, JLui, ASNajera, IRajyaguru, SSangi, MSteiner, STalamas, FXTaygerly, JPZhao, J Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B. J Med Chem56:8163-82 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6
Name:Cytochrome P450 2D6
Synonyms:CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50441246
n/a
NameBDBM50441246
Synonyms:CHEMBL2431456
TypeSmall organic molecule
Emp. Form.C25H30N2O4S
Mol. Mass.454.582
SMILESCOc1c(CCc2ccc(NS(C)(=O)=O)cc2)cc(cc1C(C)(C)C)-c1ccc[nH]c1=O
Structure
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