Reaction Details |
| Report a problem with these data |
Target | Cytochrome P450 2D6 |
---|
Ligand | BDBM50441246 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_984595 (CHEMBL2434089) |
---|
IC50 | >5000±n/a nM |
---|
Citation | Schoenfeld, RC; Bourdet, DL; Brameld, KA; Chin, E; de Vicente, J; Fung, A; Harris, SF; Lee, EK; Le Pogam, S; Leveque, V; Li, J; Lui, AS; Najera, I; Rajyaguru, S; Sangi, M; Steiner, S; Talamas, FX; Taygerly, JP; Zhao, J Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B. J Med Chem56:8163-82 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cytochrome P450 2D6 |
---|
Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
|
|
|
BDBM50441246 |
---|
n/a |
---|
Name | BDBM50441246 |
Synonyms: | CHEMBL2431456 |
Type | Small organic molecule |
Emp. Form. | C25H30N2O4S |
Mol. Mass. | 454.582 |
SMILES | COc1c(CCc2ccc(NS(C)(=O)=O)cc2)cc(cc1C(C)(C)C)-c1ccc[nH]c1=O |
Structure |
|