Reaction Details |
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Target | E3 ubiquitin-protein ligase XIAP |
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Ligand | BDBM50441341 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_984067 (CHEMBL2434425) |
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IC50 | 65±n/a nM |
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Citation | Donnell, AF; Michoud, C; Rupert, KC; Han, X; Aguilar, D; Frank, KB; Fretland, AJ; Gao, L; Goggin, B; Hogg, JH; Hong, K; Janson, CA; Kester, RF; Kong, N; Le, K; Li, S; Liang, W; Lombardo, LJ; Lou, Y; Lukacs, CM; Mischke, S; Moliterni, JA; Polonskaia, A; Schutt, AD; Solis, DS; Specian, A; Taylor, RT; Weisel, M; Remiszewski, SW Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain. J Med Chem56:7772-87 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase XIAP |
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Name: | E3 ubiquitin-protein ligase XIAP |
Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
Type: | Protein |
Mol. Mass.: | 56685.27 |
Organism: | Homo sapiens (Human) |
Description: | P98170 |
Residue: | 497 |
Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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BDBM50441341 |
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n/a |
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Name | BDBM50441341 |
Synonyms: | CHEMBL2431766 | US9394263, 1g |
Type | Small organic molecule |
Emp. Form. | C29H32BrN3O5 |
Mol. Mass. | 582.485 |
SMILES | CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11CCOCC1 |r| |
Structure |
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