| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase 2 |
|---|
| Ligand | BDBM50441357 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_984399 (CHEMBL2433123) |
|---|
| IC50 | 479±n/a nM |
|---|
| Citation |  Narwal, M; Koivunen, J; Haikarainen, T; Obaji, E; Legala, OE; Venkannagari, H; Joensuu, P; Pihlajaniemi, T; Lehtiö, L Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem56:7880-9 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Poly [ADP-ribose] polymerase 2 |
|---|
| Name: | Poly [ADP-ribose] polymerase 2 |
|---|
| Synonyms: | (ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 66225.70 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UGN5 |
|---|
| Residue: | 583 |
|---|
| Sequence: | MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
|
|
|
|---|
| BDBM50441357 |
|---|
| n/a |
|---|
| Name | BDBM50441357 |
|---|
| Synonyms: | CHEMBL2431805 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H11F3N2OS |
|---|
| Mol. Mass. | 312.31 |
|---|
| SMILES | FC(F)(F)c1ccc(cc1)-c1nc2CSCCc2c(=O)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
