Reaction Details |
| Report a problem with these data |
Target | Orexin receptor type 2 |
---|
Ligand | BDBM50318701 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_987341 (CHEMBL2438191) |
---|
Ki | 8.7±n/a nM |
---|
Citation | Betschart, C; Hintermann, S; Behnke, D; Cotesta, S; Fendt, M; Gee, CE; Jacobson, LH; Laue, G; Ofner, S; Chaudhari, V; Badiger, S; Pandit, C; Wagner, J; Hoyer, D Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J Med Chem56:7590-607 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Orexin receptor type 2 |
---|
Name: | Orexin receptor type 2 |
Synonyms: | Hcrtr2 | Hypocretin receptor type 2 | Mox2r | OX2R_MOUSE | Ox-2-R | Ox2-R | Ox2R |
Type: | PROTEIN |
Mol. Mass.: | 52478.36 |
Organism: | Mus musculus |
Description: | ChEMBL_107668 |
Residue: | 460 |
Sequence: | MSSTKLEDSLSRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVS
CIIMIPQAIVMECSSMLPGLANKTTLFTVCDEHWGGEVYPKMYHICFFLVTYMAPLCLMI
LAYLQIFRKLWCRQIPGTSSVVQRKWKQQQPVSQPRGSGQQSKARISAVAAEIKQIRARR
KTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCLGVHHRQGDRLARGRTSTESRKSLTTQISNFDNVSKLS
EHVVLTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
|
|
|
BDBM50318701 |
---|
n/a |
---|
Name | BDBM50318701 |
Synonyms: | CHEMBL1083659 | MK-4305 | [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone |
Type | Small organic molecule |
Emp. Form. | C23H23ClN6O2 |
Mol. Mass. | 450.921 |
SMILES | C[C@@H]1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2cc(Cl)ccc2o1 |r| |
Structure |
|