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TargetHeme oxygenase 2
LigandBDBM50441452
Substrate/Competitorn/a
Meas. Tech.ChEMBL_988011 (CHEMBL2438669)
IC50 1500±n/a nM
Citation Vlahakis, JZVukomanovic, DNakatsu, KSzarek, WA Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position. Bioorg Med Chem21:6788-95 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Heme oxygenase 2
Name:Heme oxygenase 2
Synonyms:HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2
Type:Enzyme
Mol. Mass.:35754.99
Organism:Rattus norvegicus (rat)
Description:HO-2 obtained from rat brain was used in enzyme assays.
Residue:315
Sequence:
MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGN
IKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENW
EEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTG
EGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAG
SMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILA
ASVALVAGLLAWYYM
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  Blast E-value cutoff:
BDBM50441452
n/a
NameBDBM50441452
Synonyms:CHEMBL2436287
TypeSmall organic molecule
Emp. Form.C19H20BrN3
Mol. Mass.370.286
SMILESBrc1cccc(Cn2c(CN3CCCC3)nc3ccccc23)c1
Structure
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