Reaction Details |
| Report a problem with these data |
Target | Phosphodiesterase |
---|
Ligand | BDBM50441528 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_988574 (CHEMBL2438433) |
---|
IC50 | 278±n/a nM |
---|
Citation | Woodring, JL; Bland, ND; Ochiana, SO; Campbell, RK; Pollastri, MP Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1). Bioorg Med Chem Lett23:5971-4 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Phosphodiesterase |
---|
Name: | Phosphodiesterase |
Synonyms: | Class 1 phosphodiesterase PDEB1 | Class I phosphodiesterase B1 (TbrPDEB1) | PDEB1 |
Type: | Protein |
Mol. Mass.: | 103683.20 |
Organism: | Trypanosoma brucei |
Description: | n/a |
Residue: | 930 |
Sequence: | MFMNKPFGSKRCEPFHESEHLCEAFAITEAILARYQRGKRSFTSSEKSGLAALIKRIPYD
ILVEVLDQSGFTPTSNATPPVDYLAMMEHTMTHGASITHALQYLNDLMTKCTGCPGIRTY
YHNPNDDVLADPVHDTAALIDETTAVGKSVVTKQYLNIAGAHYIPLIHGDIVVGCVEVPR
FSGNLEKLPSFPSLIRAVTCTAHKFIEEARINWNREKAEAMLQMATRLARDNLDETVLAS
SIMNTVKSLTESARCSLFLVKDDKLEAHFEDGNVVSIPKGTGIVGYVAQTGETVNIVDAY
ADDRFNREVDKATGYRTKTILCMPVMYEGTIVAVTQLINKLDLTTESGLRLPRVFGKRDE
ELFQTFSMFAGASLRNCRINDRLLKEKKKSDVILDVVTVLSNTDIRDVDGIVRHALHGAK
KLLNADRSTLFLVDKERNELCSRMADSVAGKEIRFPCGQGIAGTVAASGVGENIQDAYQD
PRFNREVDKQLGYRTQTILCEPIILNGEILAVVQLVNKLDTSGEVTVFTEDDRDTFRVFS
LFAGISINNSHLLEFAVKAGREVMELNEHRATLFNKNVPSRAVKRVTAITKVEREAVLVC
ELPSFDVTDVEFDLFRARESTDKPLDVAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCR
KKYRNVPYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLITALVHDLDHMGLNNSF
YLKTESPLGILSSASGNTSVLEVHHCNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCV
LATDMAKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNVTKPFDISRQWAMAV
TEEFYRQGDMEKERGVEVLPMFDRSKNMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWT
VDRIKSNRAQWERVLETRLSTSSGNNSSTR
|
|
|
BDBM50441528 |
---|
n/a |
---|
Name | BDBM50441528 |
Synonyms: | CHEMBL2436772 |
Type | Small organic molecule |
Emp. Form. | C25H34N2O2 |
Mol. Mass. | 394.5497 |
SMILES | COc1ccc(cc1OC1CCCC1)C1=NN(C[C@H]2CC=CC[C@@H]12)C1CCCC1 |r,c:22,t:16| |
Structure |
|