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TargetC-C chemokine receptor type 5
LigandBDBM50441720
Substrate/Competitorn/a
Meas. Tech.ChEMBL_988290 (CHEMBL2439744)
IC50 1.2±n/a nM
Citation Skerlj, RBridger, GZhou, YBourque, EMcEachern, EMetz, MHarwig, CLi, TSYang, WBogucki, DZhu, YLangille, JVeale, DBa, TBey, MBaird, IKaller, AKrumpak, MLeitch, DSatori, MVocadlo, KGuay, DNan, SYee, HCrawford, JChen, GWilson, TCarpenter, BGauthier, DMacfarland, RMosi, RBodart, VWong, RFricker, SSchols, D Design of substituted imidazolidinylpiperidinylbenzoic acids as chemokine receptor 5 antagonists: potent inhibitors of R5 HIV-1 replication. J Med Chem56:8049-65 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 5
Name:C-C chemokine receptor type 5
Synonyms:C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:Enzyme
Mol. Mass.:40540.21
Organism:Homo sapiens (Human)
Description:P51681
Residue:352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50441720
n/a
NameBDBM50441720
Synonyms:CHEMBL2435885
TypeSmall organic molecule
Emp. Form.C32H44ClN5O2
Mol. Mass.566.177
SMILESC[C@H](CCNC(=O)c1c(C)cc(Cl)nc1C)N1CCC(CC1)N1[C@@H](CN(C2CCCCC2)C1=O)c1ccccc1 |r|
Structure
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