Reaction Details |
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Target | E3 ubiquitin-protein ligase XIAP |
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Ligand | BDBM50441811 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_988991 (CHEMBL2437637) |
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IC50 | 15±n/a nM |
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Citation | Kester, RF; Donnell, AF; Lou, Y; Remiszewski, SW; Lombardo, LJ; Chen, S; Le, NT; Lo, J; Moliterni, JA; Han, X; Hogg, JH; Liang, W; Michoud, C; Rupert, KC; Mischke, S; Le, K; Weisel, M; Janson, CA; Lukacs, CM; Fretland, AJ; Hong, K; Polonskaia, A; Gao, L; Li, S; Solis, DS; Aguilar, D; Tardell, C; Dvorozniak, M; Tannu, S; Lee, EC; Schutt, AD; Goggin, B Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain. J Med Chem56:7788-803 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase XIAP |
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Name: | E3 ubiquitin-protein ligase XIAP |
Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
Type: | Protein |
Mol. Mass.: | 56685.27 |
Organism: | Homo sapiens (Human) |
Description: | P98170 |
Residue: | 497 |
Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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BDBM50441811 |
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n/a |
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Name | BDBM50441811 |
Synonyms: | CHEMBL2436214 | US10053431, 91b |
Type | Small organic molecule |
Emp. Form. | C27H29BrN4O4 |
Mol. Mass. | 553.448 |
SMILES | CN[C@@H](C)C(=O)N[C@H]1CN(C(C)=O)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O |r| |
Structure |
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