| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM50441912 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_987636 (CHEMBL2439369) |
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| Ki | 11340±n/a nM |
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| Citation |  Ali, AR; El-Bendary, ER; Ghaly, MA; Shehata, IA Novel acetamidothiazole derivatives: synthesis and in vitro anticancer evaluation. Eur J Med Chem69:908-19 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TS | TSase | TYMS | TYSY_HUMAN | Thymidylate synthase (TS) | Thymidylate synthase/GAR transformylase/AICAR transformylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 35718.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 313 |
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| Sequence: | MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
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| BDBM50441912 |
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| n/a |
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| Name | BDBM50441912 |
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| Synonyms: | CHEMBL2437295 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19ClN4O2S |
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| Mol. Mass. | 378.876 |
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| SMILES | CC(=O)N1CCN(CC1)C(=O)Cn1c(csc1=N)-c1ccc(Cl)cc1 |
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| Structure | 
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