| Reaction Details |
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 | Report a problem with these data |
| Target | DNA nucleotidylexotransferase |
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| Ligand | BDBM50442215 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_991704 (CHEMBL2445052) |
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| Ki | 500±n/a nM |
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| Citation |  Costi, R; Crucitti, GC; Pescatori, L; Messore, A; Scipione, L; Tortorella, S; Amoroso, A; Crespan, E; Campiglia, P; Maresca, B; Porta, A; Granata, I; Novellino, E; Gouge, J; Delarue, M; Maga, G; Di Santo, R New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target. J Med Chem56:7431-41 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA nucleotidylexotransferase |
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| Name: | DNA nucleotidylexotransferase |
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| Synonyms: | DNA nucleotidylexotransferase | DNTT | TDT | TDT_HUMAN | Terminal addition enzyme | Terminal deoxynucleotidyltransferase | Terminal transferase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58545.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_210231 |
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| Residue: | 509 |
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| Sequence: | MDPPRASHLSPRKKRPRQTGALMASSPQDIKFQDLVVFILEKKMGTTRRAFLMELARRKG
FRVENELSDSVTHIVAENNSGSDVLEWLQAQKVQVSSQPELLDVSWLIECIRAGKPVEMT
GKHQLVVRRDYSDSTNPGPPKTPPIAVQKISQYACQRRTTLNNCNQIFTDAFDILAENCE
FRENEDSCVTFMRAASVLKSLPFTIISMKDTEGIPCLGSKVKGIIEEIIEDGESSEVKAV
LNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKVRSDKSLKFTRMQKAGFLYYEDLV
SCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKMGHDVDFLITSPGSTEDEEQL
LQKVMNLWEKKGLLLYYDLVESTFEKLRLPSRKVDALDHFQKCFLIFKLPRQRVDSDQSS
WQEGKTWKAIRVDLVLCPYERRAFALLGWTGSRQFERDLRRYATHERKMILDNHALYDKT
KRIFLKAESEEEIFAHLGLDYIEPWERNA
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| BDBM50442215 |
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| n/a |
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| Name | BDBM50442215 |
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| Synonyms: | CHEMBL2441974 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17NO5 |
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| Mol. Mass. | 363.3634 |
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| SMILES | OC(=O)C(=O)CC(=O)C=Cc1cn(Cc2ccc(O)cc2)c2ccccc12 |w:9.9| |
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| Structure | 
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