| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin D2 receptor 2 |
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| Ligand | BDBM50296851 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_993379 (CHEMBL2444574) |
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| IC50 | 565±n/a nM |
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| Citation |  Sandham, DA; Arnold, N; Aschauer, H; Bala, K; Barker, L; Brown, L; Brown, Z; Budd, D; Cox, B; Docx, C; Dubois, G; Duggan, N; England, K; Everatt, B; Furegati, M; Hall, E; Kalthoff, F; King, A; Leblanc, CJ; Manini, J; Meingassner, J; Profit, R; Schmidt, A; Simmons, J; Sohal, B; Stringer, R; Thomas, M; Turner, KL; Walker, C; Watson, SJ; Westwick, J; Willis, J; Williams, G; Wilson, C Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorg Med Chem21:6582-91 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin D2 receptor 2 |
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| Name: | Prostaglandin D2 receptor 2 |
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| Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 43295.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5Y4 |
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| Residue: | 395 |
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| Sequence: | MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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| BDBM50296851 |
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| n/a |
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| Name | BDBM50296851 |
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| Synonyms: | 2-(1-(4-chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid | CHEMBL561539 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13ClN2O4S |
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| Mol. Mass. | 364.803 |
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| SMILES | Cc1c(CC(O)=O)c2cccnc2n1S(=O)(=O)c1ccc(Cl)cc1 |
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| Structure | 
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