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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Transient receptor potential cation channel subfamily V member 1 | ||
| Ligand | BDBM50442374 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_991133 (CHEMBL2446589) | ||
| Ki | 2.6±n/a nM | ||
| Citation |  Ha, TH; Ryu, H; Kim, SE; Kim, HS; Ann, J; Tran, PT; Hoang, VH; Son, K; Cui, M; Choi, S; Blumberg, PM; Frank, R; Bahrenberg, G; Schiene, K; Christoph, T; Frormann, S; Lee, J TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides. Bioorg Med Chem21:6657-64 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Transient receptor potential cation channel subfamily V member 1 | |||
| Name: | Transient receptor potential cation channel subfamily V member 1 | ||
| Synonyms: | Capsaicin receptor | OTRPC1 | Osm-9-like TRP channel 1 | TRPV1 | TRPV1_HUMAN | Transient receptor potential cation channel subfamily V member 1 | Transient receptor potential cation channel subfamily V member 1 (TRPV1) | Transient receptor potential cation channel subfamily V member 1 (VR1/TRPV1) | Transient receptor potential cation channel subfamily V member 1(TRPV1) | VR1 | Vanilloid VR1 | Vanilloid receptor | Vanilloid receptor 1 | Vanilloid receptor 1 (TrpV1/Vr1) | Vanilloid receptor 1 (VRI/TRPV1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 94960.75 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q8NER1 | ||
| Residue: | 839 | ||
| Sequence: |
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| BDBM50442374 | |||
| n/a | |||
| Name | BDBM50442374 | ||
| Synonyms: | CHEMBL2442919 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H35F4N3O3S2 | ||
| Mol. Mass. | 589.709 | ||
| SMILES | CC(C(=O)NCc1ccc(nc1SC1CCC(CC1)C(C)(C)C)C(F)(F)F)c1ccc(NS(C)(=O)=O)c(F)c1 |(32.42,-1.77,;32.42,-3.31,;31.09,-4.08,;29.75,-3.31,;31.09,-5.63,;29.75,-6.4,;28.41,-5.63,;28.41,-4.08,;27.08,-3.31,;25.74,-4.08,;25.74,-5.63,;27.08,-6.4,;27.08,-7.94,;25.75,-8.71,;24.42,-7.94,;23.09,-8.7,;23.09,-10.24,;24.42,-11.01,;25.76,-10.25,;21.75,-11,;20.42,-10.23,;21.75,-12.54,;20.41,-11.76,;24.4,-3.31,;24.4,-1.78,;23.07,-4.09,;23.07,-2.54,;33.76,-4.08,;33.76,-5.63,;35.09,-6.4,;36.43,-5.63,;37.76,-6.4,;37.77,-7.94,;36.44,-8.71,;38.54,-9.27,;39.3,-7.93,;36.43,-4.08,;37.77,-3.31,;35.09,-3.31,)| | ||
| Structure | 
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