Reaction Details |
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Target | Potassium voltage-gated channel subfamily KQT member 2 |
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Ligand | BDBM50442469 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_990142 (CHEMBL2444337) |
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EC50 | >10000±n/a nM |
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Citation | Wu, YJ; Conway, CM; Sun, LQ; Machet, F; Chen, J; Chen, P; He, H; Bourin, C; Calandra, V; Polino, JL; Davis, CD; Heman, K; Gribkoff, VK; Boissard, CG; Knox, RJ; Thompson, MW; Fitzpatrick, W; Weaver, D; Harden, DG; Natale, J; Dworetzky, SI; Starrett, JE Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain. Bioorg Med Chem Lett23:6188-91 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium voltage-gated channel subfamily KQT member 2 |
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Name: | Potassium voltage-gated channel subfamily KQT member 2 |
Synonyms: | KCNQ2_MOUSE | KQT-like 2 | Kcnq2 | Kqt2 | Potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2 |
Type: | PROTEIN |
Mol. Mass.: | 84494.02 |
Organism: | Mus musculus |
Description: | ChEMBL_990142 |
Residue: | 759 |
Sequence: | MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTG
GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK
SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI
AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF
LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI
GVSFFALPAGILGSGFALKVQEQHRPKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW
QYYERTVTVPMYRLIPPLNQLELLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPR
GMAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRTRQAFRIKGAASRQNSE
EASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDV
IEQYSAGHLDMLSRIKSLQSRIDMIVGPPPPSTPRDKKYPTKGPTAPSRESPQYSPRVDH
IVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIP
PAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRNYAAPPAIPPAQ
CPPSTSWQQSHQRHGTSPVGDHGSLVLRLERSAGMMSCH
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BDBM50442469 |
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n/a |
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Name | BDBM50442469 |
Synonyms: | CHEMBL2440362 |
Type | Small organic molecule |
Emp. Form. | C22H19FN2O2 |
Mol. Mass. | 362.3969 |
SMILES | C[C@@H](NC(=O)\C=C\c1ccccc1F)c1cccc(Oc2cccnc2)c1 |r| |
Structure |
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