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TargetATP-sensitive inward rectifier potassium channel 1
LigandBDBM50442591
Substrate/Competitorn/a
Meas. Tech.ChEMBL_990661 (CHEMBL2443483)
IC50 2500±n/a nM
Citation Tang, Hde Jesus, RKWalsh, SPZhu, YYan, YPriest, BTSwensen, AMAlonso-Galicia, MFelix, JPBrochu, RMBailey, TThomas-Fowlkes, BZhou, XPai, LYHampton, CHernandez, MOwens, KRoy, SKaczorowski, GJYang, LGarcia, MLPasternak, A Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one. Bioorg Med Chem Lett23:5829-32 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
ATP-sensitive inward rectifier potassium channel 1
Name:ATP-sensitive inward rectifier potassium channel 1
Synonyms:ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:Enzyme Catalytic Domain
Mol. Mass.:44809.08
Organism:Homo sapiens (Human)
Description:gi_223460826
Residue:391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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  Blast E-value cutoff:
BDBM50442591
n/a
NameBDBM50442591
Synonyms:CHEMBL2441412
TypeSmall organic molecule
Emp. Form.C24H23F3N6O3
Mol. Mass.500.473
SMILESFC(F)(F)c1cc(CC(=O)N2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1-n1cnnn1
Structure
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