Reaction Details |
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Target | Inward rectifier potassium channel 4 |
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Ligand | BDBM50442600 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_990653 (CHEMBL2443475) |
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IC50 | >50000±n/a nM |
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Citation | Tang, H; de Jesus, RK; Walsh, SP; Zhu, Y; Yan, Y; Priest, BT; Swensen, AM; Alonso-Galicia, M; Felix, JP; Brochu, RM; Bailey, T; Thomas-Fowlkes, B; Zhou, X; Pai, LY; Hampton, C; Hernandez, M; Owens, K; Roy, S; Kaczorowski, GJ; Yang, L; Garcia, ML; Pasternak, A Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one. Bioorg Med Chem Lett23:5829-32 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Inward rectifier potassium channel 4 |
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Name: | Inward rectifier potassium channel 4 |
Synonyms: | HIR | HIRK2 | HRK1 | Hippocampal inward rectifier | IRK-3 | IRK3 | Inward rectifier K(+) channel Kir2.3 | KCNJ4 | KCNJ4_HUMAN | Potassium channel, inwardly rectifying subfamily J member 4 |
Type: | PROTEIN |
Mol. Mass.: | 49496.50 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1515519 |
Residue: | 445 |
Sequence: | MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLM
IFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNG
FLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKK
RAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQR
DLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMT
TQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITV
LPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFG
SHLDLERMQASLPLDNISYRRESAI
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BDBM50442600 |
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n/a |
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Name | BDBM50442600 |
Synonyms: | CHEMBL2441437 | US9056859, 1 |
Type | Small organic molecule |
Emp. Form. | C23H24N6O3 |
Mol. Mass. | 432.4751 |
SMILES | O=C(Cc1ccc(cc1)-n1cnnn1)N1CCN(CCc2ccc3C(=O)OCc3c2)CC1 |
Structure |
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