| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine receptor H3 |
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| Ligand | BDBM50442628 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_990753 (CHEMBL2443820) |
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| Ki | 0.500000±n/a nM |
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| Citation |  Gao, Z; Hurst, WJ; Czechtizky, W; Francon, D; Griebel, G; Nagorny, R; Pichat, P; Schwink, L; Stengelin, S; Hendrix, JA; George, PG Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleep-wake disorders. Bioorg Med Chem Lett23:6141-5 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine receptor H3 |
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| Name: | Histamine receptor H3 |
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| Synonyms: | n/a |
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| Type: | Enzyme |
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| Mol. Mass.: | 48611.84 |
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| Organism: | Macaca mulatta (Rhesus macaque) |
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| Description: | Q865E1 |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAG
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEQCWK
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| BDBM50442628 |
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| n/a |
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| Name | BDBM50442628 |
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| Synonyms: | CHEMBL2441640 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H33N3O |
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| Mol. Mass. | 355.5169 |
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| SMILES | C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)C2CCCC2)c(C)c1 |r| |
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| Structure | 
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