| Reaction Details |
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 | Report a problem with these data |
| Target | Monocarboxylate transporter 4 |
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| Ligand | BDBM50442717 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_989589 (CHEMBL2444904) |
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| IC50 | 1250±n/a nM |
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| Citation |  Draoui, N; Schicke, O; Fernandes, A; Drozak, X; Nahra, F; Dumont, A; Douxfils, J; Hermans, E; Dogné, JM; Corbau, R; Marchand, A; Chaltin, P; Sonveaux, P; Feron, O; Riant, O Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem21:7107-17 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monocarboxylate transporter 4 |
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| Name: | Monocarboxylate transporter 4 |
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| Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49474.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104604 |
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| Residue: | 465 |
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| Sequence: | MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
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| BDBM50442717 |
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| n/a |
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| Name | BDBM50442717 |
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| Synonyms: | CHEMBL2442515 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11FO5 |
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| Mol. Mass. | 314.2646 |
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| SMILES | OC(=O)c1cc2ccc(OCc3ccc(F)cc3)cc2oc1=O |
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| Structure | 
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