| Reaction Details |
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 | Report a problem with these data |
| Target | Maternal embryonic leucine zipper kinase |
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| Ligand | BDBM50442759 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_989468 (CHEMBL2443995) |
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| IC50 | >10.0±n/a nM |
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| Citation |  Brasca, MG; Mantegani, S; Amboldi, N; Bindi, S; Caronni, D; Casale, E; Ceccarelli, W; Colombo, N; De Ponti, A; Donati, D; Ermoli, A; Fachin, G; Felder, ER; Ferguson, RD; Fiorelli, C; Guanci, M; Isacchi, A; Pesenti, E; Polucci, P; Riceputi, L; Sola, F; Visco, C; Zuccotto, F; Fogliatto, G Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90). Bioorg Med Chem21:7047-63 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Maternal embryonic leucine zipper kinase |
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| Name: | Maternal embryonic leucine zipper kinase |
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| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) |
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| Type: | Enzyme |
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| Mol. Mass.: | 74665.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14680 |
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| Residue: | 651 |
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| Sequence: | MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
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| BDBM50442759 |
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| n/a |
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| Name | BDBM50442759 |
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| Synonyms: | CHEMBL2443138 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N4O5 |
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| Mol. Mass. | 452.5029 |
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| SMILES | CN(C)c1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(C)CC2)cc1 |
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| Structure | 
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