| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50442864 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_990378 (CHEMBL2446014) |
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| IC50 | 7800±n/a nM |
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| Citation |  Bondada, L; Rondla, R; Pradere, U; Liu, P; Li, C; Bobeck, D; McBrayer, T; Tharnish, P; Courcambeck, J; Halfon, P; Whitaker, T; Amblard, F; Coats, SJ; Schinazi, RF Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors. Bioorg Med Chem Lett23:6325-30 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50442864 |
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| n/a |
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| Name | BDBM50442864 |
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| Synonyms: | CHEMBL2441773 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H55N7O6 |
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| Mol. Mass. | 693.8759 |
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| SMILES | CCCC(NC(=O)C1N(CC11CCCCC1)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cnccn1)C1CCCCC1)C(C)(C)C)C(=O)C(=O)NC1CC1 |r| |
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| Structure | 
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