Reaction Details |
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Target | Tyrosine-protein kinase ITK/TSK |
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Ligand | BDBM50443181 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1276382 (CHEMBL3088400) |
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Ki | 0.600000±n/a nM |
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Citation | MacKinnon, CH; Lau, K; Burch, JD; Chen, Y; Dines, J; Ding, X; Eigenbrot, C; Heifetz, A; Jaochico, A; Johnson, A; Kraemer, J; Kruger, S; Krülle, TM; Liimatta, M; Ly, J; Maghames, R; Montalbetti, CA; Ortwine, DF; Pérez-Fuertes, Y; Shia, S; Stein, DB; Trani, G; Vaidya, DG; Wang, X; Bromidge, SM; Wu, LC; Pei, Z Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK). Bioorg Med Chem Lett23:6331-5 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase ITK/TSK |
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Name: | Tyrosine-protein kinase ITK/TSK |
Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
Type: | Protein |
Mol. Mass.: | 71839.20 |
Organism: | Homo sapiens (Human) |
Description: | Q08881 |
Residue: | 620 |
Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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BDBM50443181 |
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n/a |
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Name | BDBM50443181 |
Synonyms: | CHEMBL3086535 |
Type | Small organic molecule |
Emp. Form. | C23H23N5OS |
Mol. Mass. | 417.527 |
SMILES | CN(C)Cc1ccc(cc1)C1CC1C(=O)Nc1nc2ccc(cc2s1)-c1cn[nH]c1 |
Structure |
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