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TargetHistamine receptor H3
LigandBDBM50443217
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1276755 (CHEMBL3089263)
Ki 0.400000±n/a nM
Citation Gao, ZHurst, WJCzechtizky, WHall, DMoindrot, NNagorny, RPichat, PStefany, DHendrix, JAGeorge, PG Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)phenyl] amide as histamine H(3) receptor antagonist for the treatment of depression. Bioorg Med Chem Lett23:6269-73 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine receptor H3
Name:Histamine receptor H3
Synonyms:n/a
Type:Enzyme
Mol. Mass.:48611.84
Organism:Macaca mulatta (Rhesus macaque)
Description:Q865E1
Residue:445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAG
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEQCWK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50443217
n/a
NameBDBM50443217
Synonyms:CHEMBL3087669
TypeSmall organic molecule
Emp. Form.C22H30N4O2
Mol. Mass.382.4992
SMILESC[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2c(C)noc2C)c(C)c1 |r|
Structure
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