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TargetPotassium voltage-gated channel subfamily H member 2
LigandBDBM50443217
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1276747
IC50 44000±n/a nM
Citation Gao ZHurst WJCzechtizky WHall DMoindrot NNagorny RPichat PStefany DHendrix JAGeorge PG Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)phenyl] amide as histamine H(3) receptor antagonist for the treatment of depression. Bioorg Med Chem Lett 23:6269-73 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium voltage-gated channel subfamily H member 2
Name:Potassium voltage-gated channel subfamily H member 2
Synonyms:CERG | DERG | ERG | ERG-1 | Eag-related protein 1 | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related protein 1 | KCNH2 | Voltage-gated potassium channel subunit Kv11.1 | c-ERG
Type:PROTEIN
Mol. Mass.:126660.03
Organism:Canis familiaris
Description:ChEMBL_107964
Residue:1158
Sequence:
MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM
QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG
AVIMFILNFEVVMEKDMVGSPTHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTTRESSA
RPGGVGSAGAPGAVVVDVDLSPAVPSRESLALDEVTAMDNHVAGLGPMEEQRALVGSSSP
PAGAPEPLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGLPPPPR
HASTGAMHPLRGGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAP
KIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYT
AVFTPYSAAFLLKETEEGPPAPDCGYACQPLAVVDFIVDIMFIVDILINFRTTYVNANEE
VVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDR
YSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSG
LGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSA
IIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFP
ECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYF
ISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEV
LDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSAELEGGFNRQRKRKLSFRRRTDRDPEQ
PGEVSALGPGRAGAGPSGRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSP
RPPGEPPGGEPLTEDGEKSSDTCNPLSGAFSGVSNIFSFWGDSRGHQYQELPRCPAPTPS
LLNIPLSSPCRRPRGDVEGRLDALQRQLNRLETRLSADMATVLQLLQRQMTLIPPAYSAV
TTPGPGPTSTSSLLPVSPIPTLTLDSLSQVSQFMAFEELPPGAPELPQDGPPRRLSLPGQ
LGALTSQPLHRHGSDPGS
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  Blast E-value cutoff:
BDBM50443217
n/a
NameBDBM50443217
Synonyms:CHEMBL3087669
TypeSmall organic molecule
Emp. Form.C22H30N4O2
Mol. Mass.382.4992
SMILESC[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2c(C)noc2C)c(C)c1 |r|
Structure
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