| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM50443313 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1274589 (CHEMBL3089847) |
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| Ki | 390±n/a nM |
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| Citation |  Ferrari, S; Calò, S; Leone, R; Luciani, R; Costantino, L; Sammak, S; Di Pisa, F; Pozzi, C; Mangani, S; Costi, MP 2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives. J Med Chem56:9356-60 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TSase | TYSY_LACCA | Thymidylate Synthase (TS) | Thymidylate synthase | thyA |
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| Type: | Enzyme |
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| Mol. Mass.: | 36576.54 |
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| Organism: | Lactobacillus casei |
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| Description: | n/a |
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| Residue: | 316 |
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| Sequence: | MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSE
LLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHE
EMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRL
IVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV
AHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIK
LLNYDPYPAIKAPVAV
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| BDBM50443313 |
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| n/a |
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| Name | BDBM50443313 |
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| Synonyms: | CHEMBL3088233 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H9NO4 |
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| Mol. Mass. | 315.2791 |
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| SMILES | O=C(Oc1ccc2OC(=O)c3cccc1c23)c1cccc(c1)C#N |
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| Structure | 
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