Reaction Details |
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Target | Lysosomal Pro-X carboxypeptidase |
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Ligand | BDBM50443348 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1275524 (CHEMBL3090539) |
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IC50 | 0.280000±n/a nM |
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Citation | Debenham, JS; Graham, TH; Verras, A; Zhang, Y; Clements, MJ; Kuethe, JT; Madsen-Duggan, C; Liu, W; Bhatt, UR; Chen, D; Chen, Q; Garcia-Calvo, M; Geissler, WM; He, H; Li, X; Lisnock, J; Shen, Z; Tong, X; Tung, EC; Wiltsie, J; Xu, S; Hale, JJ; Pinto, S; Shen, DM Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorg Med Chem Lett23:6228-33 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysosomal Pro-X carboxypeptidase |
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Name: | Lysosomal Pro-X carboxypeptidase |
Synonyms: | PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase |
Type: | PROTEIN |
Mol. Mass.: | 55028.96 |
Organism: | Mus musculus |
Description: | ChEMBL_1335505 |
Residue: | 491 |
Sequence: | MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
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BDBM50443348 |
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n/a |
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Name | BDBM50443348 |
Synonyms: | CHEMBL3086040 | US8669252, 12 |
Type | Small organic molecule |
Emp. Form. | C29H30BrClFN3O2 |
Mol. Mass. | 586.923 |
SMILES | Fc1cc(ccn1)C(NC(=O)[C@@H]1CC[C@H](C[C@H]1c1ccc(Br)cc1)N1CCOCC1)c1ccc(Cl)cc1 |r| |
Structure |
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