| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM50443500 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1275023 |
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| IC50 | 12710±n/a nM |
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| Citation |  Bavetsias V; Faisal A; Crumpler S; Brown N; Kosmopoulou M; Joshi A; Atrash B; Pérez-Fuertes Y; Schmitt JA; Boxall KJ; Burke R; Sun C; Avery S; Bush K; Henley A; Raynaud FI; Workman P; Bayliss R; Linardopoulos S; Blagg J Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells. J Med Chem 56:9122-35 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIM-1 | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM50443500 |
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| n/a |
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| Name | BDBM50443500 |
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| Synonyms: | CHEMBL3087784 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19ClN6O2 |
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| Mol. Mass. | 458.9 |
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| SMILES | Cc1nn(C)cc1-c1nc2ncc(Cl)c(Oc3ccc(cc3)C(=O)Nc3ccccc3)c2[nH]1 |
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| Structure | 
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