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TargetNuclear receptor subfamily 1 group I member 2
LigandBDBM50443610
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1279400 (CHEMBL3096556)
EC50 10800±n/a nM
Citation Shao, PPYe, FChakravarty, PKHerrington, JBDai, GBugianesi, RMHaedo, RJSwensen, AMWarren, VASmith, MMGarcia, MLMcManus, OBLyons, KALi, XGreen, MJochnowitz, NMcGowan, EMistry, SSun, SYAbbadie, CKaczorowski, GJDuffy, JL Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide. ACS Med Chem Lett4:1064-8 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor subfamily 1 group I member 2
Name:Nuclear receptor subfamily 1 group I member 2
Synonyms:NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:Nuclear receptor
Mol. Mass.:49774.77
Organism:Homo sapiens (Human)
Description:O75469
Residue:434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
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  Blast E-value cutoff:
BDBM50443610
n/a
NameBDBM50443610
Synonyms:CHEMBL3092204
TypeSmall organic molecule
Emp. Form.C23H24ClF3N2O5S2
Mol. Mass.565.025
SMILESCS(=O)(=O)c1ccc(C(=O)N2CCC(CC2)N(C2CC2)S(=O)(=O)c2cccc(c2)C(F)(F)F)c(Cl)c1
Structure
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