| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Sgk1 |
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| Ligand | BDBM50443628 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1279842 (CHEMBL3095701) |
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| IC50 | 690±n/a nM |
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| Citation |  Blass, B N-[4-(1H-Pyrazolo[3,4-B]pyrazin-6yl)-phenyl]-sulonamides and Their Use As Pharmaceuticals. ACS Med Chem Lett4:1022-4 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Sgk1 |
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| Name: | Serine/threonine-protein kinase Sgk1 |
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| Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 48954.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. |
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| Residue: | 431 |
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| Sequence: | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
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| BDBM50443628 |
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| n/a |
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| Name | BDBM50443628 |
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| Synonyms: | CHEMBL3092468 | US9174993, 35 | US9221828, 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12ClFN6O2S |
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| Mol. Mass. | 418.833 |
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| SMILES | Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 |
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| Structure | 
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