| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Ligand | BDBM50443638 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1280764 (CHEMBL3097748) |
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| IC50 | 130±n/a nM |
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| Citation |  Burgy, G; Tahtouh, T; Durieu, E; Foll-Josselin, B; Limanton, E; Meijer, L; Carreaux, F; Bazureau, JP Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines. Eur J Med Chem62:728-37 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Synonyms: | DYRK2 | DYRK2_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66690.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1508025 |
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| Residue: | 601 |
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| Sequence: | MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNA
AAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLP
VVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE
IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAY
DHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMT
FELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG
RSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYP
LLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGG
RSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP
KPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLV
S
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| BDBM50443638 |
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| n/a |
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| Name | BDBM50443638 |
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| Synonyms: | CHEMBL3092863 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30N4O7 |
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| Mol. Mass. | 498.5283 |
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| SMILES | NCCOCCOCCOCCOc1ccc(NC2=NC(=Cc3ccc4OCOc4c3)C(=O)N2)cc1 |w:21.21,t:18| |
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| Structure | 
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